After seeing a reference to http://userstyles.org/styles/11133 by tha_sun in IRC I went ahead and played with it a bit. I ended up with a very simple version that that just removes the blocks and makes the issue table full width. While I was at it I customized Google.

If you do not know where to put this checkout, per-site custom CSS in Firefox.

@namespace url('http://www.w3.org/1999/xhtml');

@-moz-document url-prefix('http://drupal.org/project/issues/') {
  #spacer {}

  #contentwrapper {
    background: none !important;
  }

  #main {
    margin-left: 5px;
    margin-right: 5px;
  }

  #threecol, #content, #squeeze {
    width: 100% !important;
    margin: 0 !important;
    padding: 0 !important;
  }

  .sidebar .block {
    display: none !important;
  }
}

@-moz-document url('http://www.google.com/') {
  #spacer {}

  #ghead, td[align='left'], td[width='25%'], #body > center > font, input[name='btnG'], input[name='btnI'], #footer {
    display: none;
  }

  #main > center {
    margin-top: 250px;
  }
}